Constitutive Properties of Adult Mammalian Cardiac Muscle Cells

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Constitutive properties of adult mammalian cardiac muscle cells.

BACKGROUND The purpose of this study was to determine whether changes in the constitutive properties of the cardiac muscle cell play a causative role in the development of diastolic dysfunction. METHODS AND RESULTS Cardiocytes from normal and pressure-hypertrophied cats were embedded in an agarose gel, placed on a stretching device, and subjected to a change in stress (sigma), and resultant c...

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Some mechanical properties of isolated mammalian cardiac muscle.

Isolated preparations of mammalian cardiac muscle have been employed to study possible mechanisms responsible for changes in diastolic compliance. Muscles have been studied at rest and during isometric and afterloaded contractions, at fixed initial length and during programmed, cyclic changes in length, and under the influence of paired stimulation, catecholamines, and elevated extracellular ca...

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Electron Microscope Study of Mammalian Cardiac Muscle Cells

The cellular theory of heart muscle is supported by a detailed description of the intercalary discs. The discs are adjacent plasma membranes separated by an interspace while the sarcolemma appears as plasma membrane, interspace plus basement membrane of the interstitium. The nucleus of the cell is closely associated with the entire cell by way of the endoplasmic reticulum. Transversely it conne...

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Physiological loading of isolated mammalian cardiac muscle.

Cat papillary muscles were subjected to a complex loading function resulting from an analysis of the heart as a pump. The papillary muscle was assumed to be a hypothetical bundle of circumferential muscle fibers in the wall of a simplified cylindrical ventricle. The loading included inertial, resistive, and capacitive components of the cardiovascular system. Changes of ventricular dimensions we...

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The Ultrastructure of Mammalian Cardiac Muscle

Papillary muscles of rat and dog hearts were fixed in such a way as to prevent excessive shortening during the procedure. The material was embedded in either araldite or methacrylate and was stained in various ways. The filamentous fine structure of mammalian cardiac muscle is similar to that previously described for striated skeletal muscle. The sarcomeres are composed of a set of thick and th...

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ژورنال

عنوان ژورنال: Circulation

سال: 1998

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.98.6.567